AbinoNutra®️NMN (β-Nicotinamide Mononucleotide) Bulk Powder

Introduction:

NMN bulk powder, branded as AbinoNutra®️NMN, is one of our major dietary supplement ingredients. Our NMN is manufactured in a US FDA registered facility under strict cGMP with purity >99.0%, was recognized by US FDA-accredited experts as SA-GRAS, and has been commercialized in the US and Japan since 2020. We keep multiple hundred kilograms of high purity NMN dietary ingredient in stock for your need at anytime.

NMN bulk powder, AbinoNutra®️NMN, NMN, AbinoNutra

AbinoNutra®️NMN Human Clinical Trial:

We successfully conducted a randomized, placebo-controlled, double-blinded, parallel human clinical trial on our AbinoNutra®️NMN dietary supplement ingredient in collaboration with our partners (ProRelix and AbaChem) and Professor Andrea Maier of the Healthy Longevity Center at National University of Singapore. The results of human clinical trial with our AbinoNutra®️NMN dietary supplemental ingredient was published in GeroScience. A brief summary of our human clinical trial was shown below:

AbinoNutra®️NMN Human Clinical Study Design
A randomized, multicenter, double-blind, placebo-controlled, parallels-group, dose-dependent (300mg, 600mg, and 900mg) clinical trial in healthy 40-65 years old adults. The details of the design is shown in below graph.

AbinoNutra®️NMN Supplementation on Blood NAD Concentration
After both 30 and 60 days of our NMN supplementation, blood NAD concentrations were significantly increased at all three doses (300mg, 600mg, and 900mg) compared to both placebo and baseline. The increases of NAD concentration over baseline were between 1.5 - 4.7 fold. The 600mg dose gave significant higher NAD concentration than the 300mg while there were no significant difference between 900mg and 600mg. The details are shown in below graph and table. For a general review on how NAD concentration affects human healthy longevity, please see my blog “NMN —- Is It the Fountain of Youth We Are Looking For?”.

AbinoNutra®️NMN Supplementation on Physical Strength
Our clinical trial measured the impact of our NMN supplementation on healthy adults’ physical strength by testing participants’ walking distance in 6 minutes (6-minute walking distance, a international standard for such test) after both 30 and 60 days. The 6-minute walking distance were significantly increased at all three doses (300mg, 600mg, and 900mg) compared to both placebo and baseline with only exception of the comparison over baseline for 300mg at day 30 . The quantitative analysis revealed the increases were between 14%-50% over baseline. Again, the 600mg dose gave significant longer walking distance than the 300mg while there were no significant difference between 900mg and 600mg. The details are shown in below graph and table.

AbinoNutra®️NMN Supplementation on Biological Age
Biological age is currently a very popular measurement of the real healthy condition of a person in the academic world and is gradually put into practical use to general population by several biotechnology companies. Several studies have found out that some people are much younger than their chronical age (actual age) while some are much older than their “real age”. Regular exercises and proper nutritional intervention have proven to be able to lower people’s biological age. Our clinical trial measured the impact of our NMN supplementation on healthy adult participants’ biological age by using a blood biological age calculator, called Aging.Ai 3.0, based on 19 blood test parameters and developed by Insilico Medicine, Inc. After 60 days of supplementation of our NMN, the increase of biological age was found significantly lower at all three doses (300mg, 600mg, and 900mg) compared to placebo’s. The quantitative analysis revealed that the placebo group’s biological age increased almost 14% during the 60 days while those of all three NMN groups only increased between -2.5% - 3.6%. The 600mg group even saw their mean biological age 1 year younger when compared to their mean biological age 60 days ago before they took our NMN. However, we didn’t see significant difference when comparing 600mg vs 300mg and 900mg vs 600mg. We believe longer study time is necessary to find out the differences with different doses. The details are shown in below graph and table.

AbinoNutra®️NMN Supplementation on Overall Health
We used 36-Item Short Form Survey (SF-36 Questionnaire), the internally recognized method for evaluation of overall health or quality of life, to assess the impact of our NMN supplementation for 30 and 60 days. The responses of participants to the 36 health-related questions were collected, scored (SF-36 score) and analyzed by statistician. The SF-36 scores were significantly increased at all three doses (300mg, 600mg, and 900mg) compared to both placebo and baseline with only exception for the 300mg at day 30 . The quantitative analysis revealed the increases were between 6.0%-16%. Again, we didn’t see significant difference when comparing 600mg vs 300mg and 900mg vs 600mg. Longer study time is necessary to find out the differences with different doses. The details are shown in below graph and table.

AbinoNutra®️NMN Supplementation on Safety and Tolerability
Safety evaluation of NMN supplementation was to assess if NMN would cause significant changes to clinical lab parameters from blood and urinary samples and to adverse events (AE) when compared to placebo and baseline. Supplementation with our NMN was found safe and well-tolerated up to 900mg oral daily dose during the 60-day study.

Summary of All Human Clinical Trials on NMN Supplementation Published So Far
The following table we compiled is a summary of all the human clinical trials on NMN published so far. We intended to constantly update the table if there is any new NMN human clinical trial published. From the results in below table, NMN is safe and well-tolerated, but the results of efficacy of NMN from different manufacturers are showing significant differences. For example, some human clinical studies did not gave statistically significant increase of human blood NAD concentration at all.

AbinoNutra®️NMN Supplementation Summary
Our human clinical study with our AbinoNutra®️NMN supplementation increases blood NAD concentrations and is safe and well tolerated with oral dosing up to 900 mg NMN daily. Clinical efficacy expressed by blood NAD concentration, physical performance and overall health assessment reaches highest at a dose of 600 mg daily oral intake. This trial was registered with ClinicalTrials.gov, NCT04823260

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Media Coverages of Our AbinoNutra®️NMN Human Clinical Trial
Since the results of our AbinoNutra®️NMN human clinical trial was published online in GeroScience in December 2022 as shown in below picture, our human clinical trial gained broad media coverages and generated great excitement on overall anti-aging research and nutritional supplementations: