NAD+ was first discovered in 1906. After over 100 years of studies, scientists now have a very good understanding of its biological activities in our human bodies and its corresponding functions to human health. A summary of NAD+ is shown below:

Will the excellent healthy longevity efficacy observed on animals repeats on human beings? So far only a handful human clinical studies on NMN were done. The results were summarized in below tables. From these published results, we can see a mixed bag of we had hope for. Some of these studies failed to observe the elevation of human tissue NAD+ levels while a few others reported significantly increases of NAD+ concentrations by NMN supplementation. Some studies even saw beneficial human healthy longevity effects, such as improving physical strength, increasing muscle insulin sensitivity, etc. Our own human clinical study published on GeroScience revealed that our AbinoNutra®️NMN can elevate blood NAD+ concentration 1.5-4.7 fold after daily oral administration of 300mg, 600mg, or 900mg NMN for 30-60 days and significantly improves physical strength, biological age and overall health of healthy mid-aged adults. Our study also revealed 600mg oral daily dose give the optimum results. Finally, so far, all human clinical studies confirmed that NMN is safe and well-tolerated at as high as 2 grams daily oral intake.

All in all, based on above discussion, NMN is a natural product that exist in several vegetables in low quantity and also in all cells of human body. It is a key precursor of Coenzyme I (NAD+). Within short time after animals take NMN orally, the NAD+ level in the cells of various tissues increases dramatically. NMN has been clinically proven to be safe in human for up to 500mg. Many prominent scientists in the world have conducted extensive studies on the possibility of reversing aging and discovered NAD+ plays a key role in the aging process. NAD+ level decreases with aging. It has been confirmed that increasing the level of NAD+ in aged animals can reverse the aging and relieve many age-related diseases. NMN supplement is a safe and efficient way to help increase the NAD+ level of our bodies.